Hackberry grows naturally in moist bottomland soil but will grow rapidly in a variety of soil types from moist, fertile soils to hot, dry, rocky locations in the full sun. Hackberry is tolerant of highly alkaline soil whereas Sugarberry is not. It is wind, drought, salt and pollution tolerant once established and is considered a moderately tough, urban-tolerant tree. Skilled pruning is required several times during the first 15 years of life to prevent formation of weak branch crotches and weak multiple trunks.

It was extensively used in street plantings in parts of Texas and in other cities as it tolerates most soils except extremely alkaline (pH > 8), and grows in sun or partial shade but branches may break out from the trunk if proper pruning and training is not conducted early in the life of the tree. Even slight injury to the trunk and branches can initiate extensive decay inside the tree. If you use this tree, locate it where it will be protected from mechanical injury. Best for low-use areas such as along the edge of woods or in an open lawn, not for along streets. The tree is very susceptible to damage in an ice storm.

This Metallic Wood-boring Beetle's host plant is Hackberry.  Agrilus lecontei

Pests
The most common insect on Hackberry causes the Hackberry nipple gall. A pouch or gall forms on the lower leaf surface in response to feeding. There are sprays available if you care to reduce this cosmetic problem. Scales of various types may be found on Hackberry. These may be partially controlled with horticultural oil sprays. Several fungi cause leaf spots on Hackberry. The disease is worse during wet weather but chemical controls are seldom needed. Witches broom is caused by a mite and powdery mildew. The main symptom is clusters of twigs scattered throughout the tree crown. Prune out the clusters of twigs when practical. It is most common on Celtis occidentalis.

Powdery mildew may coat the leaves with white powder. The leaves may be uniformly coated or only in patches. Mistletoe is an effective colonizer of Hackberry, which can kill a tree over a period of time. It appears as evergreen masses several feet in diameter scattered about the crown [1]