"Witch Hazel" is an astringent extracted from the leaves and bark of the shrub. Witch hazel is mainly used externally on sores, bruises and swelling. The main constituents of the extract include tannin, gallic acid, catechins, proanthocyanins, flavonoids (kaempferol, quercitin), essential oil (carvacrol, eugenol, hexenol), choline, saponins, and bitters. Distilled Witch Hazel sold in drug stores and pharmacies typically contains no tannin. Essential oil of witch hazel is not sold separately as a consumer product. The plant does not produce enough essential oil to make production viable. However, there are various distillates of witch hazel (called hydrosols or hydrolats) that are gentler than the "drug store" witch hazel, which contains alcohol.

Witch hazel hydrosol is used in skincare. It is an anti-oxidant and astringent, which supposedly makes it useful in fighting acne. It has been recommended for psoriasis, eczema, cracked or blistered skin, for treating insect bites, poison ivy, and as a treatment for varicose veins and hemorrhoids.